The Tumor Microenvironment
Xsphera’s platform preserves the complete tumor microenvironment from a biopsy of a patient’s tumor. This ex vivo system captures the entirety of the tumor microenvironment (TME), including immune cells, tumor cells, and stroma, and preserves it within multiple microfluidic channels. Each channel can be treated with different therapies to measure the cytotoxic efficacy and molecular response.
The Tumor Microenvironment (TME)
A human ovarian tumor in Xsphera’s platform, imaged over an 18 hour time frame. This movie highlights the highly dynamic 3D TME environment that is necessary to reproduce the in-vivo characteristics and predict a therapeutic response.
Xsphera’s platform includes cloud-based software that integrates with the laboratory environment to automatically ingest and analyze sample and treatment response data. This includes detailed analysis of patient immune profiles, cytotoxic response, cytokine response, and gene expression response.